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KMID : 0358819850120010009
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1985 Volume.12 No. 1 p.9 ~ p.13
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EFFECT OF VITAMIN A ON WOUND BURST STRENGTG IN CYCLOPHOSPHAMIDE TREATED RATS
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Jung Sang-Hoon
Ahn Sang-Tae
Kim Jin-Chul
Cho Hae-Suk
Lim Poong
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Abstract
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Cyclophosphamide lays restraints upon production of fibroblast and collagen fiber and reduce wound burst strength by acting on fibroblast in acute inflammatory phase. Vitamin A is known to increase inflammatory reaction by exerting an effect upon inflammatory cells in the beginning of the wound healing process. It shows contrary effect to cyclophosphamide.
In order to study the influence of vitamin A over wound healing delay induced by cyclophosphamide in rats, we observed and compared the wound burst strength of cyclophosphamide and vitamin A combined treated group with those of control and cyclophosphamide treated group. Wound burst strength of each group was measured in the skin segments of 2×4cm obtained from the operation sites at the 3rd, 5th, 7th and 14th postoperative days after making 5cm incision and suture at the back of 72 rats.
Results of the experiment are as follows;
1. Wound burst strength in control group increases slowly as days go by and shows trends of sudden increase between the 5th and 7th postoperative days.
2. Wound burst strength in cyclophosphamide treated group is markedly less than that in control group.
3. Wound burst strength in cyclophosphamide and vitamin a combined treated group shows similar level to that in control group.
4. Body weight in cyclophosphamide treated group reduces gradually as days go by. But there’s no weight reduction in cyclophosphamide and vitamin A combined treated group.
Judging from these results, we found the fact that vitamin A could prevent or recuperate the side effects of cyclophosphamide, delay of wound healing and worsening of general condition.
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